Authors: Nicole A Beard Lan Wei Angela Fay Dulhunty
Publish Date: 2009/05/12
Volume: 39, Issue: 1, Pages: 27-
Abstract
This review focuses on molecular interactions between calsequestrin triadin junctin and the ryanodine receptor in the lumen of the sarcoplasmic reticulum These interactions modulate changes in Ca2+ release in response to changes in the Ca2+ load within the sarcoplasmic reticulum store in striated muscle and are of fundamental importance to Ca2+ homeostasis since massive adaptive changes occur when expression of the proteins is manipulated while mutations in calsequestrin lead to functional changes which can be fatal We find that calsequestrin plays a different role in the heart and skeletal muscle enhancing Ca2+ release in the heart but depressing Ca2+ release in skeletal muscle We also find that triadin and junctin exert independent influences on the ryanodine receptor in skeletal muscle where triadin alone modifies excitation–contraction coupling while junctin alone supports functional interactions between calsequestrin and the ryanodine receptor“Proteins membranes and cells the structure–function nexus” Contributions from the annual scientific meeting including a special symposium in honour of Professor Alex Hope of Flinders University South Australia of the Australian Society for Biophysics held in Canberra ACT Australia September 28–October 1 2008
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