Authors: Minoru Miyashita ShinIchi Miyatake Yoshio Imahori Kunio Yokoyama Shinji Kawabata Yoshinaga Kajimoto MasaAki Shibata Yoshinori Otsuki Mitsunori Kirihata Koji Ono Toshihiko Kuroiwa
Publish Date: 2008/06/20
Volume: 89, Issue: 2, Pages: 239-
Abstract
Here we demonstrate that differentiation between glioblastoma GB tumor progression TP and radiation necrosis RN can be achieved with fluoridelabeled boronoalanine positron emission tomography FBPAPET FBPAPET images were obtained from histologically verified 38 GB 8 complete RN and 5 RN cases with partial residual tumors The lesion/normal L/N ratios for these groups were 42 ± 14 15 ± 03 and 20 ± 03 respectively Ten GB patients underwent FBPAPET twice once before and once after radiation treatment due to enlargement of the original lesion or the development of new lesions post radiation The L/N ratios of ten original site lesions had decreased by the second PET and these lesions were revealed to be RN In contrast the L/N ratios of two lesions distant from the original site increased and these lesions were revealed as cases of TP Repeat PET imaging was found to be useful for evaluating changes in GBassociated tumor activity with respect to the treatment receivedThis work was partly supported by a GrantinAid for Scientific Research B 16390422 19390385 from the Japanese Ministry of Education Culture Sports Science and Technology to ShinIchi Miyatake This work was also supported in part by the Takeda Science Foundation for Osaka Medical College We are also grateful to Mr Horii at Nishijin Hospital for technical support with the PET study
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