Authors: Haihui Jiang Xiaohui Ren Wei Zhang Jun Ma Dali Sui Zhongli Jiang Xiangli Cui Song Lin
Publish Date: 2012/12/27
Volume: 111, Issue: 3, Pages: 367-375
Abstract
This study was designed to select molecular markers associated with prognosis and to propose a prognostic scoring scale for patients with primary WHO grade III gliomas based on these molecular predictors A series of 83 grade III glioma patients surgically treated and pathologically confirmed in Beijing Tiantan Hospital between May 2009 and December 2010 were retrospectively reviewed in the study Logrank analysis was used to identify molecular markers associated with progressionfree survival PFS and overall survival OS which were further assessed using Cox regression analysis Based on the prognostic molecular markers a scoring scale was proposed and Kaplan–Meier plots were compared between different scoring levels by Logrank method Age 50 1p/19q codeletion IDH1/2 mutation negative MGMT and EGFR expression were correlated with longer PFS and OS Cox regression confirmed age 50 and 1p/19q codeletion as independent prognostic markers This scoring scale mainly based on prognostic molecular markers stratified patients into four levels with different prognoses Longer PFS and OS were correlated with higher scores P 005 This scoring scale based on prognostic molecular markers identified four levels with significantly different prognoses and could be used to predict the prognosis of patients with primary WHO grade III gliomas
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