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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1007/bf01582880

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1573-7373

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Type 2 diabetes mellitus and obesity are independe

Authors: Lola B Chambless Scott L Parker Laila HassamMalani Matthew J McGirt Reid C Thompson
Publish Date: 2011/08/11
Volume: 106, Issue: 2, Pages: 383-389
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Abstract

Type 2 diabetes mellitus DM and obesity are known risk factors for poor outcomes in patients with systemic malignancies but are not wellstudied in the brain tumor population In this study we asked if type 2 DM and elevated body mass index BMI are independent risk factors for poor prognosis in patients with highgrade glioma HGG We conducted a retrospective cohort study of 171 patients surgically treated for HGG at a single institution BMI and records of preexisting type 2 DM were obtained from medical histories Variables associated with survival in a univariate analysis were included in the multivariate Cox model if P  010 Variables with probability values 005 were then removed from the multivariate model in a stepwise fashion Mean age at diagnosis was 550 ± 173 years Fifteen 88 patients had a history of type 2 DM Fiftyeight 358 patients had a BMI  25 55 340 BMI 25–30 and 49302 BMI  30 Radiation therapy temozolomide and higher KPS score were independently associated with prolonged survival while increasing age was associated with decreased survival DM P = 0001 and increasing BMI P = 0003 were found to be independently associated with decreased survival Diabetics had a decreased median overall survival 312 vs 470 days P = 0003 and PFS 106 vs 166 days P = 004 compared to nondiabetics Increasing BMI 25 25–30 and 30 was also associated with decreased median PFS 195 vs 165 vs 143 days respectively Preexisting DM and elevated BMI are independent risk factors for poor outcome in patients with HGG

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