Authors: YongSheng Jiang FuRong Wang
Publish Date: 2013/05/24
Volume: 114, Issue: 1, Pages: 25-32
Abstract
Regardless of their cell type of origin all aggressive brain tumors such as malignant gliomas and metastatic tumors produce brain edema which is an important cause of patient morbidity and mortality Caloric restriction CR has long been recognized as a natural therapy that improves health promotes longevity and significantly reduces both the incidence and growth of many tumor types The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas We found that CR significantly inhibited the intracerebral tumor growth attenuated brain edema and ultimately prolonged survival of mice with U87 gliomas Plasma corticosterone level was found higher and serum VEGF and IGF1 levels were found lower in CR when compared to AL group CR upregulated tight junction proteins including claudin1 claudin5 and ZO1 downregulated VEGF and VEGFR2 enhanced αSMA expression and reduced AQP1 expression in U87 gliomas In addition CR suppressed inducible nitric oxide synthase iNOS expression and nitric oxide NO formation in U87 gliomas In conclusion CR attenuated edema in U87 orthotopic mouse glioma model associated with elevation of corticosterone suppression of VEGF/VEGFR2 improvement of tight junctions and suppression of iNOS expression and NO formation Our results suggested that CR might be an effective therapy for recurrent malignant brain cancers through alleviating associated edema
Keywords: