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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1016/0014-2999(92)90563-j

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1573-7373

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Caloric restriction reduces edema and prolongs sur

Authors: YongSheng Jiang FuRong Wang
Publish Date: 2013/05/24
Volume: 114, Issue: 1, Pages: 25-32
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Abstract

Regardless of their cell type of origin all aggressive brain tumors such as malignant gliomas and metastatic tumors produce brain edema which is an important cause of patient morbidity and mortality Caloric restriction CR has long been recognized as a natural therapy that improves health promotes longevity and significantly reduces both the incidence and growth of many tumor types The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas We found that CR significantly inhibited the intracerebral tumor growth attenuated brain edema and ultimately prolonged survival of mice with U87 gliomas Plasma corticosterone level was found higher and serum VEGF and IGF1 levels were found lower in CR when compared to AL group CR upregulated tight junction proteins including claudin1 claudin5 and ZO1 downregulated VEGF and VEGFR2 enhanced αSMA expression and reduced AQP1 expression in U87 gliomas In addition CR suppressed inducible nitric oxide synthase iNOS expression and nitric oxide NO formation in U87 gliomas In conclusion CR attenuated edema in U87 orthotopic mouse glioma model associated with elevation of corticosterone suppression of VEGF/VEGFR2 improvement of tight junctions and suppression of iNOS expression and NO formation Our results suggested that CR might be an effective therapy for recurrent malignant brain cancers through alleviating associated edema


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  3. Origins and clinical implications of the brain tumor stem cell hypothesis
  4. Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design
  5. All- trans retinoic acid inhibits craniopharyngioma cell growth: study on an explant cell model
  6. Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma
  7. Quality of radiosurgery for single brain metastases with respect to treatment technology: a matched-pair analysis
  8. Phase II trial of temozolomide in children with recurrent high-grade glioma
  9. Management of patients with recurrence of diffuse low grade glioma
  10. Valproic acid affected the survival and invasiveness of human glioma cells through diverse mechanisms
  11. Cognitive outcome as part and parcel of clinical outcome in brain tumor surgery
  12. The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types
  13. Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma
  14. Do perfusion and diffusion MRI predict glioblastoma relapse sites following chemoradiation?
  15. A new prognostic scoring scale for patients with primary WHO grade III gliomas based on molecular predictors
  16. Extraneural metastatic medulloblastoma in an adult
  17. Incidence of craniopharyngioma in Denmark ( n = 189) and estimated world incidence of craniopharyngioma in children and adults
  18. Application of diffusion-weighted magnetic resonance imaging to predict the intracranial metastatic tumor response to gamma knife radiosurgery
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