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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1016/0022-0248(89)90017-1

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1573-7373

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AllEmphasis Type="Italic"trans/Emphasis retin

Authors: Qiang Li Chao You Liangxue Zhou Xiutian Sima Zhiyong Liu Hao Liu Jianguo Xu
Publish Date: 2013/02/20
Volume: 112, Issue: 3, Pages: 355-364
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Abstract

The ratio between FABP5 and CRABPII determines cellular response to physiological level of retinoic acid tumor cells undergo proliferation with high level of FABP5 and apoptosis with high level of CRABPII We intended to study FABP5 and CRABPII expression in craniopharyngiomas to establish craniopharyngioma cell model using explants method and to study the effect of pharmacological dose of retinoic acid on craniopharyngioma cells Expression of FABP5 and CRABPII in craniopharyngioma tissue from 20 patients was studied using immunohistochemistry Primary craniopharyngioma cell cultures were established using tissue explants method Craniopharyngioma cells were treated using various concentrations of alltrans retinoic acid and cell growth curve apoptosis expression of FABP5 CRABPII and NFκB were assayed in different groups FABP5/CRABPII ratio was significantly higher in adamatinomatous group than that in papillary group Cell cultures were established in 19 cases 95  Pharmacological level retinoic acid inhibited cell growth and induced cellular apoptosis in dose dependent manner and apoptosis rate cells treated with 30 μM retinoic acid for 24 h was 43  Also retinoic acid increased CRABPII and decreased FABP5 and NFκB expression in craniopharyngioma cells High FABP5/CRABPII ratio is observed in adamatinomatous craniopharyngioma Retinoic acid at pharmacological level induced craniopharyngioma cell apoptosis via increasing FABP5/CRABPII ratio and inhibiting NFκB signaling pathway Our study demonstrated that alltrans retinoic acid might be a candidate for craniopharyngioma adjuvant chemotherapy in futureWe thank Dr Lixing Yuan and Dr Ruizhen Jia for technical assistance in the experiments This work was supported by Grant No 30973082 and 81172411 from China National Natural Science Foundation The present study was reviewed and approved by Ethic Committee of West China Hospital and all patients or their guardians gave informed consent This study complies with the laws of People’s Republic of China

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