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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1002/chin.199222041

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1573-7373

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Effects of sequential chemotherapy of FOLFIRI/FOLF

Authors: Changxin Huang Yiqian Jiang Guangliang Duan Zhaoyang Li Lingzhi Chen Xuechun Wang
Publish Date: 2012/03/24
Volume: 108, Issue: 3, Pages: 485-490
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Abstract

The chemotherapies of FOLFOX leucovorin + 5fluorouracil + oxaliplatin and FOLFIRI folinic acid + 5fluorouracil + irinotecan are effective for a variety of malignant tumors In particular the sequential chemotherapy of FOLFOX/FOLFIRI has become the preferred postoperational treatment approach for gastrointestinal cancer and an important palliative care program for advanced cancer However the sequential chemotherapy of FOLFOX/FOLFIRI showed severe side effects due to the fact that the toxicity of the drugs can be enhanced by each other Here we report the dynamic changes in the activities of serum ACTH cortisol renin angiotensin and aldosterone in patients following multiple cycles of FOLFOX/FOLFIRI sequential chemotherapy We found that the sequential chemotherapy might cause damage to the activities of the endocrine cells and/or the sympathetic nerve and alter endocrine function specifically the ACTH–cortisol and renin–angiotensin–aldosterone axesWe sincerely thank Professor XT Cao for his scientific help in this work Also we acknowledge Dr LF Zhou for technical assistance This work was supported by grants from the National Natural Science Foundation of China 30872380 81072495 Program for Innovative Research Team in Zhejiang Province China 2010R50046 the Science and Technology Project of Zhejiang province China 2010C33006 and the Science and Technology Project of Hangzhou China 20091233Q10 We acknowledge Siemens and Abbott for their pharmaceutical and industry support

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