Authors: Evan Neill Tracy Luks Manisha Dayal Joanna J Phillips Arie Perry Llewellyn E Jalbert Soonmee Cha Annette Molinaro Susan M Chang Sarah J Nelson
Publish Date: 2017/01/25
Volume: 132, Issue: 1, Pages: 171-179
Abstract
Lowgrade gliomas can vary widely in disease course and therefore patient outcome While current characterization relies on both histological and molecular analysis of tissue resected during surgery there remains high variability within glioma subtypes in terms of response to treatment and outcome In this study we hypothesized that parameters obtained from magnetic resonance data would be associated with progressionfree survival for patients with recurrent lowgrade glioma The values considered were derived from the analysis of anatomic imaging diffusion weighted imaging and 1H magnetic resonance spectroscopic imaging data Metrics obtained from diffusion and spectroscopic imaging presented strong prognostic capability within the entire population as well as when restricted to astrocytomas but demonstrated more limited efficacy in the oligodendrogliomas The results indicate that multiparametric imaging data may be applied as a noninvasive means of assessing prognosis and may contribute to developing personalized treatment plans for patients with recurrent lowgrade gliomaAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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