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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1002/celc.201600494

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1573-7373

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Valproic acid affected the survival and invasivene

Authors: Yun Chen YaHui Tsai ShengHong Tseng
Publish Date: 2012/04/15
Volume: 109, Issue: 1, Pages: 23-33
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Abstract

The effects of valproic acid VPA on the viability apoptosis and invasiveness of two glioma cells A172 and T98G and the underlying mechanisms were studied VPA induced cytotoxicity and apoptosis and suppressed the invasiveness of both cells VPA increased the activity of matrix metalloproteinase2 MMP2 and MMP9 in A172 cells but decreased it in T98G cells siRNA blockade of reversioninducing cysteinerich protein with Kazal motifs RECK expression partially reversed VPAmediated effects in T98G cells but had no effect on A172 cells VPA increased the expression of phosphoJNK1 and phosphoERK1/2 in A172 cells but decreased it in T98G cells Inhibition of JNK1 and/or ERK1/2 partially reversed the VPA effects in A172 cells In conclusion the effects of VPA loss of viability increased apoptosis and decreased invasiveness are at least partly mediated through the RECKMMPs pathway in T98G cells and the mitogenactivated protein kinase pathways in A172 cells The action of VPA seems to be cell typespecific in glioma cells

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