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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1007/978-3-319-09093-1_10

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1573-7373

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Immunohistochemical detection of IDH1 mutation p5

Authors: Shingo Takano Yukinari Kato Tetsuya Yamamoto Mika Kato Kaneko Eiichi Ishikawa Yuta Tsujimoto Masahide Matsuda Kei Nakai Ryo Yanagiya Shunpei Morita Koji Tsuboi Akira Matsumura
Publish Date: 2012/03/07
Volume: 108, Issue: 3, Pages: 361-373
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Abstract

Isocitrate dehydrogenase 1 IDH1 mutations which are early and frequent genetic alterations in astrocytomas oligodendrogliomas oligoastrocytomas and secondary glioblastomas are specific to arginine 132 R132 Recently we established monoclonal antibodies mAbs against IDH1 mutations antiIDH1R132H and antiIDH1R132S However the importance of immunohistochemistry using the combination of those mAbs has not been elucidated For this study 164 cases of glioma were evaluated immunohistochemically for IDH1 mutations R132H and R132S using antiIDH1 mAbs HMab1 and SMab1 IDH1 mutation was detected respectively in 97 636 517 and 778 of primary grade IV secondary grade IV grade III and grade II gliomas For each grade of glioma prognostic factors for progressionfree survival and overall survival were evaluated using clinical and pathological parameters in addition to IDH1 immunohistochemistry IDH1 mutation p53 overexpression and internexin expression as evaluated using immunohistochemistry with clinical parameters such as degree of surgical removal and preoperative Karnofsky Performance Status KPS might be of greater prognostic significance than histological grading alone in grade III as well as IDH1 mutation in grade IV gliomasWe thank Yoshiko Tsukada Makiko Miyakawa Imi Saito and Junko Aita for their excellent technical assistance This work was supported in part by a GrantinAid for Scientific Research from the Ministry of Education Culture Sports Science and Technology of Japan ST YK MKK Japan Brain Foundation ST The Japanese Foundation for research and promotion of endoscopy ST Japanese Foundation for Multidisciplinary Treatment of Cancer ST Mitsubishi Pharma Research Foundation YK MKK Children Cancer Association of Japan YK Intelligent Cosmos Academic Foundation YK and Office for Gender Equality of Yamagata University MKK

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