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Title of Journal: J Neurooncol

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Abbravation: Journal of Neuro-Oncology

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Springer US

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DOI

10.1002/chin.198922324

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1573-7373

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Disparities in receipt of modern concurrent chemor

Authors: Ryan Rhome Rebecca Fisher Adília Hormigo Rahul R Parikh
Publish Date: 2016/03/12
Volume: 128, Issue: 2, Pages: 241-250
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Abstract

Temozolomide given concurrently with radiation after resection/biopsy improves survival in glioblastoma GBM The disparities in receipt of adjuvant singleagent chemotherapy and their association with outcome have not been well established Observational study of a prospectively collected database the National Cancer Database NCDB from 1998 to 2012 with median followup 124 months Among the 114979 patients in the NCDB with GBM 44531 patients were analyzed for disparities and 28279 patients were analyzed for overall survival OS Associations were assessed in a multivariable Cox proportional hazards regression model Survival was estimated using the Kaplan–Meier method Median age was 58 years Chemotherapy use was associated with male gender white race younger age ≤50 higher performance status ≥70 more extensive surgery insurance status higher income/education and treatment at academic centers all p  005 We found improved OS associated with type of insurance private insurance HR 091 95  CI 085–096 and Medicare HR 124 95  CI 116–133 both p  001 compared to uninsured and treatment at academic programs HR 086 p  001 MGMT methylation status predicted improved OS HR 054 95  CI 041–070 p  001 1year OS for patients receiving chemotherapy was 559  versus 353  for those without p  00001 After adjustment for confounders chemotherapy use remained associated with improved OS HR 064 95  CI 063–066 p  001 Chemotherapy utilization increased from 269 to 933  during the study period We have identified specific disparities in the use of chemotherapy that may be targeted to improve patient access to care Widespread adoption of adjuvant chemoradiotherapy after resection or biopsy for GBM appears to improve OSThe data used in the study are derived from a deidentified NCDB file The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methodology employed or the conclusions drawn from these data by the investigator The NCDB is a joint project of the Commission on Cancer of the American College of Surgeons and the American Cancer Society


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  1. Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma
  2. The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells
  3. Origins and clinical implications of the brain tumor stem cell hypothesis
  4. Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design
  5. All- trans retinoic acid inhibits craniopharyngioma cell growth: study on an explant cell model
  6. Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma
  7. Quality of radiosurgery for single brain metastases with respect to treatment technology: a matched-pair analysis
  8. Phase II trial of temozolomide in children with recurrent high-grade glioma
  9. Management of patients with recurrence of diffuse low grade glioma
  10. Valproic acid affected the survival and invasiveness of human glioma cells through diverse mechanisms
  11. Cognitive outcome as part and parcel of clinical outcome in brain tumor surgery
  12. The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types
  13. Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma
  14. Do perfusion and diffusion MRI predict glioblastoma relapse sites following chemoradiation?
  15. A new prognostic scoring scale for patients with primary WHO grade III gliomas based on molecular predictors
  16. Extraneural metastatic medulloblastoma in an adult
  17. Incidence of craniopharyngioma in Denmark ( n = 189) and estimated world incidence of craniopharyngioma in children and adults
  18. Application of diffusion-weighted magnetic resonance imaging to predict the intracranial metastatic tumor response to gamma knife radiosurgery
  19. Tissue thioredoxin reductase-1 expression in astrocytomas of different grades
  20. Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
  21. Multiple paraneoplastic diseases occurring in the same patient after thymomectomy
  22. Age alone is not a predictor for survival in glioblastoma
  23. Clear cell Meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases
  24. Weight of epilepsy in brain tumor patients
  25. Effects of sequential chemotherapy of FOLFIRI/FOLFOX on the endocrine axes of ACTH–cortisol and renin–angiotensin–aldosterone
  26. PI3Kinase signaling in glioblastoma
  27. Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma
  28. Gamma Knife radiosurgery for brainstem metastases: the UCSF experience
  29. Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma
  30. Health related quality of life and cognitive status in patients with glioblastoma multiforme receiving escalating doses of conformal three dimensional radiation on RTOG 98-03
  31. Role of platelet derived growth factor receptor (PDGFR) over-expression and angiogenesis in ependymoma
  32. Toxicity of tandem high-dose chemotherapy and autologous stem cell transplantation using carboplatin-thiotepa-etoposide and cyclophosphamide-melphalan regimens for malignant brain tumors in children and young adults
  33. The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells
  34. Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors
  35. Assessment of MGMT promoter methylation status in pleomorphic xanthoastrocytoma
  36. Leukoencephalopathy in long term brain metastases survivors treated with radiosurgery
  37. Variation of O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma
  38. Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma
  39. Rho GTPases in primary brain tumor malignancy and invasion
  40. Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma
  41. Giant invasive pituitary prolactinoma with falsely low serum prolactin: the significance of ‘hook effect’
  42. Type 2 diabetes mellitus and obesity are independent risk factors for poor outcome in patients with high-grade glioma
  43. Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease
  44. Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma
  45. Historical controls for phase II surgically based trials requiring gross total resection of glioblastoma multiforme
  46. Elevation of osteopontin levels in brain tumor cells reduces burden and promotes survival through the inhibition of cell dispersal
  47. Retrospective analysis of the efficacy and tolerability of levetiracetam in patients with metastatic brain tumors
  48. Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
  49. Evaluation of fluoride-labeled boronophenylalanine-PET imaging for the study of radiation effects in patients with glioblastomas
  50. Establishment of atypical-teratoid/rhabdoid tumor (AT/RT) cell cultures from disseminated CSF cells: a model to elucidate biology and potential targeted therapeutics
  51. The incidence and significance of multicentric noncontrast-enhancing lesions distant from a histologically-proven glioblastoma
  52. Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen
  53. Images in neuro oncology: Primary extraaxial cerebellopontine angle ependymoma
  54. The peabody picture vocabulary test as a pre-screening tool for global cognitive functioning in childhood brain tumor survivors
  55. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma
  56. Skull base meningiomas: neurological outcome after microsurgical resection
  57. Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center
  58. Caloric restriction reduces edema and prolongs survival in a mouse glioma model
  59. Algorithmic three-dimensional analysis of tumor shape in MRI improves prognosis of survival in glioblastoma: a multi-institutional study
  60. Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors
  61. The efficacy and safety of various dose-dense regimens of temozolomide for recurrent high-grade glioma: a systematic review with meta-analysis

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