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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Humana Press Inc

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1559-1166

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Importance of Schedule of Administration in the Th

Authors: M B Moretto B Boff D Lavinsky C A Netto J B T Rocha D O Souza S T Wofchuk
Publish Date: 2008/10/10
Volume: 38, Issue: 2, Pages: 216-219
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Abstract

Perinatal cerebral hypoxia–ischemia HI is an important cause of mortality and neurological disabilities such as cerebral palsy epilepsy and mental retardation The potential for neuroprotection in HI can be achieved mainly during the recovery period In previous work we demonstrated that guanosine Guo prevented the decrease of glutamate uptake by hippocampal slices of neonatal rats exposed to a hypoxicischemic HI insult in vivo when administrated before and after insult In the present study we compared the effect of Guo administration only after HI using various protocols When compared with the control a decrease of 3H glutamate uptake was avoided only when three doses of Guo were administered immediately 24 h and 48 h after insult or at 3 h 24 h and 48 h after injury or at 6 h 24 h and 48 h after HI These findings indicate that early Guo administration until 6 h after HI in three doses may enhance glutamate uptake into brain slices after hypoxia/ischemia probably resulting in decreased excitotoxicity

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