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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Springer US

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DOI

10.1002/jmri.21047

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1559-1166

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Vitamin D Receptor Gene Polymorphism and the Risk

Authors: Mehrnaz NarooieNejad Maryam Moossavi Adam Torkamanzehi Ali Moghtaderi Saeedeh Salimi
Publish Date: 2015/02/18
Volume: 56, Issue: 3, Pages: 572-576
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Abstract

Multiple sclerosis is one of the most widespread demyelinating diseases of the central nervous system Environmental and genetic factors are collaborating in triggering MS The role of vitamin D receptor VDR gene and its polymorphisms are highlighted as susceptible components The aim of the present study was to examine the association of single nucleotide polymorphism SNP—BsmI and FokI—in VDR gene and MS susceptibility in the South Eastern Iranian population Therefore 113 MS patients and 122 controls were recruited in the study Restriction fragment length polymorphism was performed to detect the SNPs There were no significant differences in the polymorphism of FokI rs2228570 in VDR gene among patients and controls P  005 while a significant difference was observed in BsmI rs1544410 polymorphism in healthy subjects and homozygous genotypeb/b with MS P = 0025 Results showed a protective association of homozygous genotypeb/b of BsmI with MS susceptibility in a population in South Eastern of Iran

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