Authors: Markus Kipp Akvile Norkute Sonja Johann Leila Lorenz Alena Braun Andrea Hieble Stefan Gingele Friederike Pott Janek Richter Cordian Beyer
Publish Date: 2008/03/29
Volume: 35, Issue: 2, Pages: 235-243
Abstract
Astroglia is wellknown to be integrated in the complex regulation of neuroinflammation in the central nervous system Astrocytes become activated and synthesize cytokines chemokines and prostanoids during degenerative and vulnerable processes and interact with other immunecompetent cells Degenerative disorders often occur in a brainregionspecific fashion suggesting differences in the activity and reactivity of innate immune cells We have investigated the potency of lipopolysaccharides LPS to differently stimulate astrocytes from the cortex and midbrain Astroglial cultures were prepared from Bagg albino/c mice and exposed to LPS Astrocytes from both brain areas already differed in their capacity and profile of cytokine expression under basal unstimulated conditions In response to LPS we observed both a regionspecific pattern of upregulation of distinct cytokines and differences in the extent and timecourse of activation Our data demonstrate that astrocytes reveal a regionspecific basal profile of cytokine expression and a selective areaspecific regulation of cytokines upon LPSinduced inflammation This makes astrocytes likely candidates to be responsible for regionspecific incidence rates of neurological and neurodegenerative disorders
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