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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Humana Press Inc

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DOI

10.1007/bf02966276

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ISSN

1559-1166

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Expression of RBMX After Spinal Cord Injury in Rat

Authors: Jinlong Zhang Debao Li Aiguo Shen Hui Mao Huricha Jin Wei Huang Dawei Xu Jianbo Fan Jiajia Chen Longfei Yang Zhiming Cui
Publish Date: 2012/11/22
Volume: 49, Issue: 2, Pages: 417-429
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Abstract

RBMX RNAbinding motif gene X chromosome is a heterogeneous nuclear ribonucleoprotein that associates with the spliceosome binds RNA and influences alternative splicing The gene encoding RBMX is located on chromosome Xq26 and is ubiquitously expressed However its expression and function in spinal cord injury are still unclear In this study we performed an acute spinal cord contusion injury SCI model in adult rats and investigated the dynamic changes of RBMX expression in spinal cord Western blot and immunohistochemistry analysis revealed that RBMX was present in normal spinal cord It gradually increased reached a peak at 1 day and then declined to basal levels at 14 days after spinal cord injury Double immunofluorescence staining showed that RBMX immunoreactivity was found in neurons and astrocytes but not in microglia Interestingly RBMX expression was increased predominantly in neurons and astrocytes Moreover colocalization of RBMX/proliferating cell nuclear antigen PCNA and RBMX/active caspase3 was detected in GFAP and NeuN respectively We also examined the expression profiles of active caspase3 bcl2 Bax and PCNA whose changes were correlated with the expression profiles of RBMX In conclusion this is the first description of RBMX expression in spinal cord injury Our results suggested that RBMX might play crucial roles in CNS pathophysiology after SCI

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