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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Humana Press Inc

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ISSN

1559-1166

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C6ORF192 Forms a Unique Evolutionary Branch Among

Authors: Josefin A Jacobsson Olga Stephansson Robert Fredriksson
Publish Date: 2009/08/21
Volume: 41, Issue: 2, Pages: 230-242
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Abstract

About one third of all known human proteins are membrane proteins which constitute several large families The solute carriers with over 300 known members are probably the second largest family with additional members frequently being identified We recently found a new putative solute carrier C6ORF192 belonging to the major facilitator superfamily type of proteins The gene is evolutionary highly conserved with a single copy present in each of the genomes from mouse rat chicken zebrafish tetraodon Caenorhabditis elegans and Drosophila melanogaster C6ORF192 forms a novel evolutionary branch of solute carriers and is most closely related to the solute carrier families 16 17 and 18 all members of the major facilitator superfamily Ten of the 25 members of these families show amino acid identity with C6ORF192 ranging from 21 to 27 C6ORF192 differs however structurally from these families and does not share key motifs in the transmembrane domains Expression profiling by quantitative realtime polymerase chain reaction and in situ hybridization showed that C6ORF192 transcript can be detected in several tissues both in the central nervous system and the peripheryWe would like to thank Dr Helgi B Schiöth for valuable discussion during the course of the project and Pawel Olszewski for help with analysis of in situ data The study was supported by AFA Svenska Läkaresällskapet Åke Wikberg Foundation Lars Hiertas Foundation Thurings Foundation RF Kaleens Foundation the Magnus Bergvall Foundation and Åhlens Foundation RF was supported by the Göran Gustavsson Foundation

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