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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Humana Press Inc

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DOI

10.1016/j.apsusc.2004.03.152

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ISSN

1559-1166

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Characterization of Proteasome Inhibition on Astro

Authors: QingGuo Ren Ying Yu Xiang Luo XieMin Jie DengJi Pan Wei Wang
Publish Date: 2008/12/09
Volume: 38, Issue: 1, Pages: 57-66
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Abstract

Increasing evidence indicates that proteasome inhibition occurs in multiple central nervous system CNS disorders including Alzheimer’s disease AD and Parkinson’s disease PD Compared with the extensive studies on neurons little attention is paid on the proteasome inhibition in astrocytes Here we demonstrated that lactacystin inhibited proteasome dosedependently in cultured astrocytes Simultaneously lactacystin suppressed the expression of cell cycle proteins in astrocytes and caused the proliferating astrocytes arrested at G1/S checkpoint Western blots showed that proteasome inhibition led to a decrease in cdk2 cdk4 cyclin D1 expression accompanied with an increase in p21waf1/cip1 expression The effect of chronic lowlevel proteasome inhibition on astrocytes was consistent with that in acute proteasome inhibition Furthermore increased levels of interleukin6 IL6 secretion STAT3 and phosphoSTAT3 expression were found suggesting that proteasome inhibition in astrocytes could stabilize signals of grow arrest through the JAK/STAT signaling cascade

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