Authors: Hua Zhang Linyan Yang Qingchuan Feng Yujia Fan Hong Zheng Ying He
Publish Date: 2014/02/19
Volume: 53, Issue: 2, Pages: 166-170
Abstract
The vitamin K epoxide reductase subunit 1 gene VKORC1 plays a key role in vitamin K recycling and there is a close association between VKORC1 gene singlenucleotide polymorphisms SNPs and the required dose of warfarin an anticoagulant However the association between VKORC1 SNPs and ischemic cerebrovascular disease ICVD has not been defined This case–control study involved 370 patients with ICVD and 408 healthy individuals controls from Chinese Han population Two VKORC1 gene SNPs 1639A/G and 1173T/C were genotyped by PCRRFLP method The G allele frequencies of the 1639A/G locus and C allele frequencies of the 1173T/C locus were higher in the ICVD group than in the control group p = 0014 and p = 0008 respectively Haplotype analysis showed that 1639G1173C was associated with an increased risk of ICVD odds ratio OR = 1163 95 confidence interval CI = 1137~2288 while 1639A1173T was associated with decreased risk of ICVD OR = 0620 95 CI = 0437~0880 Our findings suggested that individuals carrying the 1639G or 1173C allele might be at increased risk for ICVD Furthermore the 1639G1173C haplotype was a risk factor for ICVD and 1639A1173T was a protective factor in Chinese Han population
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