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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Springer US

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DOI

10.1007/s12105-014-0596-7

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ISSN

1559-1166

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InsulinLike Growth Factor Binding Protein2 Promo

Authors: Nianping Feng Zhuo Zhang Zhengfei Wang Haihong Zheng Fujun Qu Xijun He Chunlai Wang
Publish Date: 2015/06/16
Volume: 57, Issue: 3, Pages: 426-434
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Abstract

The contribution of endothelial progenitor cells EPCs to new vessel formation has been studied in different physiological and pathological conditions for decades As previously suggested insulinlike growth factor binding protein2 IGFBP2 may interact with integrins and promote cell migration However the role of IGFBP2 in regulation of EPC functions remains largely unknown In this present study we found that overexpression of IGFBP2 in human umbilical vein endothelial cells HUVECs promoted EPCendothelial adhesion Conversely siRNAmediated depletion of IGFBP2 inhibited oxygenglucose deprivation OGDinduced EPCendothelial adhesion Further we demonstrated that the arginineglycineaspartic acid RGD motif in its Cdomain is required for interaction with integrin α5β1 In addition treatment with IGFBP2 significantly enhanced incorporation of EPCs into tubule networks formed by HUVECs Thus our findings suggest that exogenous administration of IGFBP2 may facilitate neovascularization and improve treatment of ischemic conditionsThis work was supported by the grants from science and technology project of the Education Department of Heilongjiang Province 12521336 science project of the Health Department of Heilongjiang Province 2011–089 and the Foundation of the Second Clinical Hospital of Harbin Medical University QN201118

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