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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Springer US

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1559-1166

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Determination of the Best Concentration of Strepto

Authors: Marzieh DehghanShasaltaneh Nasser Naghdi Samira Choopani Leila Alizadeh Bahram Bolouri Ali MasoudiNejad Gholam Hossein Riazi
Publish Date: 2016/01/20
Volume: 59, Issue: 1, Pages: 24-35
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Abstract

Alzheimer’s disease AD is one of the most important disorders among neurodegenerative diseases which is characterized by neurofibrillary tangles and senile plagues Intercerebroventricular ICV streptozotocin administration is a form of sAD which was applied to examine different factors following AD Previous reports used different doses of streptozotocin STZ to create Alzheimer’s model but no standard dose has been introduced Therefore we decided to investigate the best concentration of STZ to induce a diabetic brain with lowest mortality rate and high severity of destruction We treated rats with three different doses of STZ STZ 15 225 and 3 mg/kg ICV Spatial memory for treated rats was evaluated by Morris water maze MWM Locomotor activities of rats were assessed by open field test Histological observation such as immunohistochemistry immunofluorescence and Nissl staining were performed on the brain especially in CA1 CA3 and DG regions of hippocampal neurons at residues Pser396 and Pser404 Our data suggest that although the percentage hyperphosphorylation of tau protein by injection of STZ 3 mg/kg was about 10  more than STZ 225 mg/kg compared to the control group we considered the latter doses due to no effect on motor activities and enhance the number of glial cells

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