Authors: Ali Akbar SaboorYaraghi Mohammad Hossein Harirchian Niyaz Mohammadzadeh Honarvar Sama Bitarafan Mina Abdolahi Feridoun Siassi Eisa Salehi Mohammad Ali Sahraian Mohammad Reza Eshraghian Tina Roostaei Fariba Koohdani
Publish Date: 2015/05/19
Volume: 56, Issue: 3, Pages: 608-612
Abstract
Multiple sclerosis MS is an autoinflammatory condition of the central nervous system with impaired T helper Th17 and regulatory T cell Treg balance that is involved in disease immunopathogenesis The vitamin A active metabolite retinoic acid can reestablish this imbalance through the modulation of gene expression of specific nuclear receptors including Forkhead box P3 FoxP3 At present few data exist on the impact of vitamin A supplementation on T cell balance This study reports the results of a clinical trial over a 6month period of 36 relapsingremitting MS RRMS patients that received vitamin A 25000 IU retinyl palmitate or placebo one capsule of placebo per day Peripheral blood mononuclear cells were isolated from patients and the expression of FoxP3 and transforming growth factor TGFβ gene expression was measured using realtime PCR at the beginning and end of the study The results of this study showed that vitamin A upregulated TGFβ and FoxP3 gene expression Therefore vitamin A supplementation can be considered as a new approach in MS prevention and treatment
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