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Title of Journal: J Mol Neurosci

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Abbravation: Journal of Molecular Neuroscience

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Springer US

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DOI

10.1007/bf02392252

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ISSN

1559-1166

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Emphasis Type="Italic"TLR7/Emphasis rs2897827

Authors: Lian Gu Jinying Zhou Jinjing Tan Li Su Qiugui Wei Haiyun Jiang Baoyun Liang Qianli Tang
Publish Date: 2016/07/18
Volume: 59, Issue: 3, Pages: 397-403
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Abstract

Stroke is a multifactorial disorder that has become the leading cause of death and disability worldwide Previous studies reported that TLR7 mRNA expression is associated with poor outcome of ischemic stroke IS This study aimed to assess whether TLR7 mRNA expression affects IS occurrence as well as the association of TLR7 rs2897827 with susceptibility to IS and TLR7 mRNA expression and serum apolipoprotein and lipid levels in a Chinese Han population A total of 816 stroke patients and 816 healthy controls were included in this study mRNA expression was determined by quantitative realtime PCR The Sequenom MassARRAY iPLEX platform was used to genotype the TLR7 rs2897827 polymorphism TLR7 mRNA expression of the IS cases was statistically significantly higher than that of the controls in the male or female group male P = 0014 female P = 0025 In the male IS cases TLR7 mRNA expression of the T allele carriers was statistically significantly higher than that of the C allele carriers P = 0018 However a significant difference was not observed in the female cases P = 0545 In either the male or female group the distribution of genotype or allele had no statistical significance P  0050 The ApoA1 level of the T carriers was statistically significantly higher than the C carriers in males t = −2383 P = 0020 however the ApoB and lipid levels were not associated with rs2897827 P  0050 In female patients no significant difference was observed between different genotypic/allelic carriers in serum apolipoprotein and lipid levels all P  0050 The expression of the TLR7 gene may affect IS occurrence TLR7 gene rs2897827 may influence TLR7 mRNA expression and the plasma ApoA1 level in male IS patientsThis study was supported by grants from the National Natural Science Foundation of China Grant No 81260594 the National Natural Science Foundation of China No 81473670 the Guangxi National Natural Science Foundation Grant No 2013GXNSFAA019145

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