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Title of Journal: Surg Endosc

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Abbravation: Surgical Endoscopy

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Springer-Verlag

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10.1007/s15015-015-2055-z

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1432-2218

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Mesna protects splanchnic organs from oxidative st

Authors: Petros Ypsilantis Ioannis Tentes Konstantinos Anagnostopoulos Alexandros Kortsaris Constantinos Simopoulos
Publish Date: 2008/03/27
Volume: 23, Issue: 3, Pages: 583-589
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Abstract

Wistar rats were subjected to either a CO2 pneumoperitoneum 15 mmHg for 60 min group P b pretreatment with mesna 400 mg/kg po followed by pneumoperitoneum with a 180 min interval group MP c sham operation group S or d administration of mesna only group M Fortyfive minutes after desufflation groups P and MP 60 + 45 min after the induction of anesthesia group S or 180 min after mesna administration group M tissue specimens were excised from liver kidneys jejunum and stomach Tissue oxidative state was assessed on the basis of glutathionetoglutathione disulfide ratio malondialdehyde concentration and superoxide dismutase activityPneumoperitoneum deteriorated all the oxidative stress markers in the organs studied Mesna prevented the occurrence of oxidative stress following pneumoperitoneum in all the organs studied In the absence of pneumoperitoneum the administration of mesna caused mild enhancement of the oxidative state of liver stomach and kidneys compared to sham controls

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