Authors: Hendrik Manner Andrea May Ioanna Kouti Oliver Pech Michael Vieth Christian Ell
Publish Date: 2015/06/24
Volume: 30, Issue: 4, Pages: 1364-1370
Abstract
After thermal ablation of Barrett’s esophagus BE stricture formation is reported in 5 to over 10 of patients The question arises whether submucosal fluid injection prior to ablation may lower the risk of stricture formation The aim of the present study was to evaluate the efficacy and safety of the new technique of HybridAPC which combines submucosal injection with APCPatients who had a residual BE segment of at least 1 cm after endoscopic resection of early Barrett’s neoplasia underwent thermal ablation of BE by HybridAPC Prior to thermal ablation submucosal injection of sodium chloride 09 was carried out using a flexible waterjet probe Erbejet 2 Erbe Elektromedizin Tuebingen Germany Checkup upper GI endoscopy was carried out 3 months after macroscopically complete ablation including biopsies from the neoZline and the former BE segment and recording of stricture formationFrom May 2011 to November 2012 a total of 60 patients pt were included in the study 55 pt male 92 mean age 62 ± 9 years range 42–79 Ten patients were excluded from the study In the remaining 50 pt HybridAPC ablation and checkup endoscopy at 3 months were carried out Fortyeight out of 50 pt 96 ITT 49/60 82 achieved macroscopically complete remission after a median of 35 APC sessions SD 24 range 1–10 Freedom from BE was histopathologically observed in 39/50 patients 78 There was one treatmentrelated stricture 2 Minor adverse events of HybridAPC were observed in 11 patients 22
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