Authors: Alessandro Mor Philip Omotosho Alfonso Torquati
Publish Date: 2014/05/23
Volume: 28, Issue: 10, Pages: 2815-2820
Abstract
RouxenY gastric bypass RYGB reduces most of the obesityrelated comorbidities known to increase the cardiovascular risk in obese subjects The Framingham risk score FRS is designed to be independent of body weight and estimates the 10year risk for coronary heart disease CHD myocardial infarction stroke cardiovascular disease CVD death from CHD and death from CVD Our aim was to evaluate the effectiveness of RYGB on improving the FRS when compared to a matched control group who underwent diabetes support and education program DSEIn a prospective cohort study we evaluated preoperatively and at 12 months 61 morbidly obese subjects with diabetes Thirty underwent laparoscopic RYGB and 31 received 1 year of DSE consisting of educational sessions on diet nutrition and exercise Groups were matched for gender age weight blood pressure and cholesterol and triglyceride levels Strict genderspecific FRS was used to assess the cardiovascular riskExcess weightloss percentages EWL were 556 ± 151 in the RYGB group and 12 ± 108 in the DSE group P 0001 The two groups were matched for baseline FRS RYGB patients experienced a significant decrease in all FRS whereas control subjects did not show a significant decrease for the 10year risk for CHD CVD and death from CVD The betweengroup differences for changes from baseline to 12 months in all FRS were significant The 10year risk reductions for CHD MI stroke CVD death from CHD and death from CVD in the RYGB group relative to the DSE group were respectively 42 48 30 39 50 and 50 No correlations between reduction in FRS and EWL were found after RYGB
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