Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Wien Klin Wochenschr

Search In Journal Title:

Abbravation: Wiener klinische Wochenschrift

Search In Journal Abbravation:

Publisher

Springer Vienna

Search In Publisher:

DOI

10.1007/s11027-016-9719-7

Search In DOI:

ISSN

1613-7671

Search In ISSN:
Search In Title Of Papers:

Thrombocyte counts in mice after the administratio

Authors: Kathiresan Sathasivam Surash Ramanathan Sharif M Mansor Mas Rosemal M H Haris Walther H Wernsdorfer
Publish Date: 2009/10/01
Volume: 121, Issue: 3, Pages: 19-
PDF Link

Abstract

Following up a popular use of crude leaf preparations from Carica papaya for the treatment of dengue infections a suspension of powdered Carica papaya leaves in palm oil has been investigated for its effect on thrombocyte counts in mice administering by gavage 15 mg of powdered leaves per kg body weight to 5 mice Equal numbers of animals received corresponding volumes of either palm oil alone or physiological saline solution Thrombocyte counts before and at 1 2 4 8 10 12 24 48 and 72 hours after dosing revealed significantly higher mean counts at 1 2 4 8 10 and 12 after dosing with the C papaya leaf formulation as compared to the mean count at hour 0 There was only a nonsignificant rise of thrombocyte counts in the group having received saline solution possibly the expression of a normal circadian rhythm in mice The group having received palm oil only showed a protracted increase of platelet counts that was significant at hours 8 and 48 and obviously the result of a hitherto unknown stimulation of thrombocyte release The results call for a doseresponse investigation and for extending the studies to the isolation and identification of the C papaya substances responsible for the release and/or production of thrombocytesAngeregt von dem volksmedizinischen Gebrauch von Papaya carica Blattmaterial zur Behandlung von Dengueinfektionen wurde eine Suspension von pulversisierten Carica papaya Blättern in Palmöl auf die Beeinflussung der Thrombozytenzahlen bei Mäusen untersucht Jeweils 5 Mäuse erhielten peroral 15 mg der Carica papaya Blattsuspension gleiche Volumina physiologischer Kochsalzlösung oder Palmöl Die Thrombozytenzahl wurde unmittelbar vor sowie 1 2 4 8 10 12 24 48 und 72 Stunden nach der Applikation bestimmt Bei den mit C papaya behandelten Mäusen zeigte sich eine signifikante Erhöhung der Thrombozytenzahl 1 2 4 8 10 und 12 Stunden nach der Anwendung Die mit physiologischer Kochsalzlösung behandelte Gruppe zeigte lediglich eine zeitweilige nicht signifikante Erhöhung der Thrombozytenzahlen offenbar Ausdruck eines zirkadischen Zyklus In der mit Palmöl allein behandelten Gruppe wurde eine protrahierte bei 8 und 48 Stunden signifikante Erhöhung der Thrombozytenzahl verzeichnet möglicherweise als Folge einer bisher unbekannten Stimulation der Freisetzung von Thrombozyten Die Ergebnisse legen eine erweiterte Dosisstudie nahe sowie die Isolierung und strukturelle Aufklärung der für die Ausschüttung bzw Produktion von Thrombozyten verantwortlichen Inhaltsstoffe von C papaya


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Epidemiology of suicide in Austria during 2000–2010: potential years of life lost: time for the national suicide prevention program
  2. An outbreak of acute gastroenteritis associated with group A Rotavirus in long-term care facility in Slovenia
  3. Lung cancer in pregnancy
  4. Synergism between pyronaridine and retinol in Plasmodium vivax in vitro
  5. AGO Austria recommendations for genetic testing of patients with ovarian cancer
  6. The role of inflammation in the pathophysiology of acute coronary syndromes
  7. The role of inflammation in the pathophysiology of acute coronary syndromes
  8. The antibiotic prescription and redemption gap and opportunistic CRP point-of-care testing. A cross-sectional study in primary health care from Eastern Austria
  9. Prognostic nutritional index as a predictor of prognosis in patients with diffuse large B cell lymphoma
  10. Daytime sleepiness in patients with obstructive sleep apnea and severe obesity: prevalence, predictors, and therapy
  11. Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty
  12. Management of dabigatran-induced bleeding: expert statement
  13. Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease
  14. Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?
  15. Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia
  16. 4. Österreichischer Konsensusbericht zur Diagnose und Therapie der Hepatitis B 2009
  17. Cardiac surgery for metastatic melanoma
  18. Effective penile block for circumcision in adults
  19. Prevalence and pattern of spinal pathologies in a consecutive series of CTs/MRIs in an urban and rural Tanzanian hospital – a retrospective neuroradiological comparative analysis
  20. In-hospital cardiac arrest: can we change something?
  21. Prescription of benzodiazepines in Slovenian family medicine: a qualitative study
  22. Salmonella typhimurium osteomyelitis of the femur in patient with Crohn's disease
  23. Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in patients with hip fracture
  24. Intermediate to long-term follow-up results of INH chemoprophylaxis prior to anti-TNF-alpha therapy in a high-risk area for tuberculosis

Search Result: