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Title of Journal: Wien Klin Wochenschr

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Abbravation: Wiener klinische Wochenschrift

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Springer-Verlag

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10.1016/0098-7913(83)90063-1

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1613-7671

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Synergism between pyronaridine and retinol in Emp

Authors: Julia Riedl Gunther Wernsdorfer Kanungnit Congpuong Ursula Wiedermann Jeeraphat Sirichaisinthop Walther H Wernsdorfer
Publish Date: 2010/10/08
Volume: 122, Issue: 3, Pages: 66-70
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Abstract

Estimates of the annual number of infections with Plasmodium vivax reach 391 million So far the bloodschizontocidal therapy with chloroquine remained effective in most parts of the world but reports about emerging resistance are increasing The study had the objective of determining the pharmacodynamic interaction between pyronaridine and retinol in Plasmodium vivax since pyronaridine is a potential alternative for chloroquine and an earlier study had shown strong synergism between pyronaridine and retinol in Plasmodium falciparum The study was conducted at the Malaria Clinic of MAE Sot Tak Province Thailand near the border to Myanmar The in vitro observations followed the method of Tasanor Successful tests were performed with 44 isolates The mean IC50 IC90 and IC99 values for pyronaridine were 98 20696 and 1624465 nM The mean IC50 IC90 and IC99 values for the combinations with retinol corresponding to the 50th 65th and 80th percentile of the physiological retinol levels in healthy adults were 17 5428 and 593795 nM for pyronaridine + retinol low for the combination with retinol medium they were 05 3137 and 588914 nM and for the combination with retinol high they were 02 967 and 167543 nM These results suggest strong synergism between the two substancesSchätzungsweise erkranken weltweit jährlich bis zu 391 Millionen Menschen an Malaria tertiana hervorgerufen durch Plasmodium vivax Bislang ist die blutschizontozide Therapie mit Chloroquin in weiten Teilen der Erde noch erfolgreich doch die Berichte über Resistenzentwicklungen nehmen zu Die Studie hatte das Ziel die pharmakodynamische Interaktion von Pyronaridin und Retinol bei Plasmodium vivax zu untersuchen da Untersuchungen bei Plasmodium falciparum auf hochgradigen Synergismus zwischen beiden Substanzen hinweisen und Pyronaridin eines der möglichen Ersatzmedikamente bei Eintritt von Chloroquinresistenz ist Die Arbeiten wurden 2009 an der Malariaklinik von MAE Sot Provinz Tak Thailand nahe der Grenze zu Myanmar durchgeführt Die invitro Prüfungen folgten der Methode von Tasanor und ergaben für 44 Isolate erfolgreiche parallele Tests Die mittleren IC50 IC90 und IC99 Werte für Pyronaridin betrugen 98 20696 und 1624465 nM und konnten durch Zugabe von Retinol entsprechend Konzentrationen der 50 65 und 80 Perzentile der physiologischen Retinolspiegel gesunder Erwachsener auf 17 5428 und 593795 nM für Pyronaridin + Retinol low auf 05 3137 und 588914 nM für Pyronaridin + Retinol medium und auf 02 967 und 167543 nM für Pyronaridin + Retinol high gesenkt werden Diese Ergebnisse weisen auf starken Synergismus zwischen beiden Substanzen hin


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