Authors: Vlatka Periša Lada Zibar Ana Knezović Igor Periša Jasminka SinčićPetričević Igor Aurer
Publish Date: 2016/09/08
Volume: 129, Issue: 11-12, Pages: 411-419
Abstract
The prognostic nutritional index PNI an indicator of nutritional status and systemic inflammation is associated with shortterm and longterm outcomes of various malignancies The prognostic value of PNI in diffuse large B cell lymphoma DLBCL remains unknown The aim of the present study was to determine the prognostic value of baseline PNI in DLBCL patientsPatients with a PNI ≤ 4455 where the cutoff was calculated by receiver operating characteristics Youden index and the same was obtained for response to treatment with 762 sensitivity and a specificity of 854 for OS with 724 sensitivity and a specificity of 905 and for EFS with 656 sensitivity and a specificity of 901 had significantly worse 5‑year OS 183 vs 864 P 0001 log rank test and 5‑year EFS 151 vs 823 P 0001 log rank test Regression analysis showed that PNI ≤ 4455 was an independent prognostic factor for response to treatment with an odds ratio OR of 488 for treatment failure 95 confidence interval CI 1077–22105 OS hazard ratio HR 424 95 CI 1451–12392 and EFS HR 4007 95 CI 148–10852 Lower PNI levels were found in patients with advanced Ann Arbor clinical stage 466 ± 777 vs 527 ± 543 and in those with poor response to therapy 4058 ± 726 vs 5067 ± 626The PNI is a simple and useful marker to predict longterm survival outcome in DLBCL patients Low PNI predicted poor outcome A limitation of the study is its retrospective design in which the prognostic value was tested in the derivation cohort only Notwithstanding this is the first study suggesting that PNI is an important prognostic factor in DLBCL
Keywords: