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Title of Journal: Wien Klin Wochenschr

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Abbravation: Wiener klinische Wochenschrift

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Springer-Verlag

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1613-7671

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4 Österreichischer Konsensusbericht zur Diagnose

Authors: Markus PeckRadosavljevic Johann Deutsch Peter Ferenci Ivo Graziadei Harald Hofer Heidemarie Holzmann WolfDietrich Huber Herman Laferl Andreas Maieron Rudolf Stauber Wolfgang Vogel
Publish Date: 2010/05/04
Volume: 122, Issue: 9-10, Pages: 280-302
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Abstract

Die Hepatitis B ist die häufigste chronische Virusinfektion der Leber Sie betrifft zumindest geschätzte 350 Millionen Menschen weltweit und ist die häufigste leberbedingte Todesursache In der letzten Zeit gab es dramatische Entwicklungen sowohl in der Diagnostik als auch in der Medikamentenentwicklung der chronischen Hepatitis B Heute ist die chronische Hepatitis B in der überwiegenden Mehrzahl der Patienten eine gut behandelbare Erkrankung und die wichtigste Herausforderung bleibt die rechtzeitige Identifikation der betroffenen Patienten bevor diese eine fortgeschrittene Lebererkrankungen mit den assoziierten Komplikationen erleiden Die rasche Entwicklung der medikamentösen Therapie verlangte nach einer Neufassung der Österreichischen Konsensusempfehlungen zur Behandlung der Hepatitis B welche bisher nach den Versionen von 1994 und 1998 in ihrer dritten Version von 2005 vorlagen Alle Kapitel des 3 KonsensusStatements von 2005 wurden überarbeitet mit Ausnahme des Kapitels über die Leberbiopsie welches weiterhin in der Version von 2005 Gültigkeit hat Im Speziellen spielen nun virologische Parameter für Behandlungsentscheidungen eine zentrale Rolle die HBVGenotypisierung wird nun für die Wahl des Therapeutikums vermehrt in Betracht gezogen und die orale Erstlinientherapie für die chronische Hepatitis B hat sich verändert Dieser KonsensusBericht beinhaltet die entscheidenden Fortschritte der Behandlung der Hepatitis B und verändert das klinische Management von Patienten mit Hepatitis B in Österreich entscheidendHepatitis B is the most common chronic viral infection of the liver Chronic hepatitis B is estimated to affect at least 350 million people worldwide and is the leading cause of death from liver disease There have been dramatic developments both in the diagnostic field and in drug treatment of chronic hepatitis B Today chronic hepatitis B is a well manageable disease in the vast majority of cases and the main challenge remains the detection of affected patients at an early enough disease stage to prevent endstage liver disease and its complications The rapid pace of drug development mandated an update of the Austrian guidelines on the treatment of hepatitis B which after 1994 and 1998 were now dating back to 2005 in their third version All chapters from the 3 consensus statement from 2005 were renewed except for the chapter on liver biopsy which is still valid in its 2005version In particular virologic parameters take now center stage for treatment decisions HBVgenotyping is now being considered for the choice of treatment and the oral first line treatment for chronic hepatitis B has been changed Overall this consensus statement accounts for the major advances in the management of hepatitis B and significantly changes clinical management of patients with hepatitis B in Austria


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