Authors: A Smithson C Chico J Ramos C Netto M Sanchez J Ruiz R Porron M T Bastida
Publish Date: 2011/07/15
Volume: 31, Issue: 4, Pages: 423-430
Abstract
The purpose of this study was to evaluate the prevalence and clinical risk factors for quinolone resistance QR in E coli strains from males with febrile urinary tract infection FUTI An ambispective crosssectional study was performed in which we evaluated 153 males with a community FUTI caused by E coli Among the 153 FUTI episodes 101 66 were due to quinolone susceptible E coli strains while 52 34 were caused by QR E coli strains In the univariate analysis QR was associated with older age higher Charlson scores dementia past UTI urinary tract abnormalities previous antibiotic use particularly with fluoroquinolones FQ a healthcareassociated HAUTI HAUTI and to four of the components included in the definition of HAUTI hospital admission nursing home residence indwelling urethral catheter and invasive urinary instrumentation In the multivariate analysis HAUTI OR 382 95 CI 13–1124 P 0015 and use of antimicrobials in the previous month OR 582 95 CI 23–1488 P 0001 mainly with FQ OR 1397 95 CI 273–7153 P 0002 were associated with QR To have a HAUTI and a previous use of FQ in the preceding month were strong risk factors for QR E coli and thus empirical antimicrobial treatment with quinolones should be avoided in these patients
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