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Title of Journal: Eur J Clin Microbiol Infect Dis

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Abbravation: European Journal of Clinical Microbiology & Infectious Diseases

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Springer-Verlag

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DOI

10.1007/bf02810994

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1435-4373

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In vivo evaluation of a metronidazolecontaining g

Authors: P K Miani C do Nascimento S Sato A V Filho M J V da Fonseca V Pedrazzi
Publish Date: 2011/12/06
Volume: 31, Issue: 7, Pages: 1611-1618
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Abstract

The present study developed an experimental metronidazolebased gel and evaluated its efficacy for the adjuvant treatment of chronic periodontitis Sixteen patients were randomly allocated into two groups of eight subjects according to the following proposed treatments 1 scaling and root planing active control or 2 scaling and root planing and direct periodontal intrapocket application of 15 metronidazolebased gel in two sites ≥5 mm in depth experimental group Potential changes in the subgingival microbiota were assessed using a DNA Checkerboard method at three proposed times baseline and following 7 or 30 days of drug administration Highperformance liquid chromatography HPLC monitored metronidazole concentrations in the crevicular fluid during treatment The metronidazole experimental group presented lower bacterial counts than the control group at the three evaluated times p  001 for baseline p  0001 for 7 or 30 days when the target species were analyzed as a pool of bacteria Samples revealed significantly lower counts 7 days after drug administration compared with baseline or after 30 days p  005 HPLC analysis detected gel 1 h after application The metronidazolebased gel significantly decreased the total bacterial count at the three evaluated times Periodontopathogenic species were not different after gel administration


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