Authors: R A Ali R H Elsherif M A Saleh M H Ismail
Publish Date: 2016/07/11
Volume: 35, Issue: 11, Pages: 1749-1752
Abstract
The purpose of this study was to screen pemphigus vulgaris PV autoimmune bullous skin disease for the presence of immunoglobulin G against Mycobacterium tuberculosis and Aspergillus fumigatus The sera of 60 PV patients and 28 controls were screened for the presence of immunoglobulin G against M tuberculosis and A fumigatus by enzymelinked immunesorbent assay Forty patients were females and 20 were males The range of IgG against M tuberculosis was from 09 to 1526 median = 295 in the patients and was from 0 to 22 median = 16 in the controls Seven 117 patients and none of the controls exceeded the cutoff value Four patients were on systemic steroids and azathioprine and three did not receive treatment before The results showed that PV patients had significantly more IgG against M tuberculosis than the controls the p value was 0006 The range of IgG against A fumigatus was from 13 to 763 median = 49 in the patients and was from 1 to 1053 median = 525 in the controls Six 10 patients and eight 286 controls exceeded the cutoff value The six patients were on systemic steroids and azathioprine No significant difference was detected between PV patients and controls regarding exposure to A fumigatus the p value was 0308 PV patients showed significantly more exposure to the M tuberculosis than the controls This suggests that M tuberculosis may contribute to the pathogenesis of PV
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