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Title of Journal: Eur J Clin Microbiol Infect Dis

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Abbravation: European Journal of Clinical Microbiology & Infectious Diseases

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Springer Berlin Heidelberg

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DOI

10.1007/s11042-016-4171-y

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1435-4373

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Emphasis Type="Italic"Mycobacterium tuberculosis

Authors: H He H Yang Y Deng
Publish Date: 2015/02/05
Volume: 34, Issue: 6, Pages: 1103-1109
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Abstract

Onethird of the world’s human population is latently infected with Mycobacterium tuberculosis M tb and adult tuberculosis TB is largely caused by the resuscitation of latent M tb Rv2660c an M tb dormancyrelated antigen is preferentially expressed during latent infection Identification and characterization of Rv2660c are crucial to understanding host–pathogen interactions and to develop drug target and vaccine candidates In this study Tcell and antibody immune responses against recombinant Rv2660c protein were respectively investigated in latent M tb infection LTBI cases pulmonary tuberculosis PTB patients and healthy individuals HI After stimulation with recombinant Rv2660c protein stronger cellular responses were induced in LTBI cases compared with those in PTB patients or in HI Meanwhile Rv2660c stimulated higher levels of IgG IgG1 and IgG2a antibody titers in LTBI cases compared with those in PTB patients The results showed that Rv2660c is able to elicit prominent cellular immune responses and strong humoral immunity in a Chinese LTBI population suggesting that Rv2660c is a potential target to develop new vaccines and drugs to control LTBI

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