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Title of Journal: Res Chem Intermed

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Abbravation: Research on Chemical Intermediates

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Springer Netherlands

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DOI

10.1007/bf02282198

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1568-5675

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Synthesis and antimicrobial activity of some novel

Authors: YuTing Liu GuiDan Lian DaWei Yin BaoJun Su
Publish Date: 2011/11/22
Volume: 38, Issue: 3-5, Pages: 1043-1053
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Abstract

In the present investigation a series of ferrocenebased Schiff bases 5a–m were synthesized by the condensation of various chalcones 3a–m with Sbenzyl dithiocarbazate in absolute ethanol using catalytic amount of glacial acetic acid and characterized by element analysis1H NMR13C NMR and IR The synthesized compounds were screened for their in vitro antimicrobial activity against four bacterias Staphylococcus aureus ATCC 9144 Bacillus cereus ATCC 11778 Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 43288 and two fungals Aspergillus niger ATCC 9092 and Aspergillus fumigatus ATCC 46645 strains The Schiff bases 5g 5h and 5m against Grampositive bacterial E coli and P aeruginosa strains was found to be higher than that for the standard drug They are potential new drugs in antibacterial activity aspects in further daysThe authors are indebted to Prof Yuting Liu for her constant support and encouragement The authors also thank Prof Zhiwei Zhang for having carried out all the antimicrobial activity tests The authors are thankful to Shaanxi University of Science Technology for FTIR elemental 13CNMR and 1HNMR analysis

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