Journal Title
Title of Journal: Res Chem Intermed
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Abbravation: Research on Chemical Intermediates
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Publisher
Springer Netherlands
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Authors: Shenghui Li Shan Ding Shengjie Xu Jinchao Zhang Shuxiang Wang Chuanqi Zhou Xiaoliu Li
Publish Date: 2013/03/03
Volume: 40, Issue: 5, Pages: 2091-2102
Abstract
An efficient synthetic method for 18dioxodecahydroacridines derivatives bearing the biologically active sulfonamide moiety is described Aromatic aldehyde reacted with 55dimethyl13cyclohexanedione and sulfanilamide with molecular iodine as catalyst to give 18dioxodecahydroacridines derivatives in high to excellent yield The structures of these compounds were established on the basis of elemental C H and N and spectral analysis 1H NMR 13C NMR MS and FTIR All the compounds were tested for their cytotoxic activity in vitro against three human tumor cell lines human mammary cancer cells MCF7 human cervical carcinoma cells Hela and human lung cancer cells A549 by the 345dimethylthiazol2yl25diphenyltetrazolium bromide MTT assay Most of them showed moderate to potent cytotoxic activity against the tested cell lines Among them the most active compound 4e exhibited more efficient activity 1092 μM against MCF7 cells than cisplatin 1106 μMWe are grateful to the National Basic Research 973 Program Grant No 2010CB534913 Hebei Provincial Natural Science Foundation of ChinaShijiazhuang Pharmaceutical Group CSPC Foundation B2011201174 Hebei Province Nature Science Fund for Distinguished Young Scholars B2011201164 the Nature Science Fund of Hebei Province B2011201135 the Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province 11966412D 12966418D and Open Fund of Key Laboratory of Chemical Biology of Hebei Province No 09265631D7
Keywords:
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