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Title of Journal: Res Chem Intermed

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Abbravation: Research on Chemical Intermediates

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Springer Netherlands

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DOI

10.1002/chin.199706245

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ISSN

1568-5675

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Pharmacological evaluation of isochromen1ones an

Authors: A Arumugham Napoleon Swati Bhagwat FazlurRahman Nawaz Khan
Publish Date: 2012/07/12
Volume: 39, Issue: 3, Pages: 1343-1351
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Abstract

The 313benzoylphenylethyl1Hisochromen1one 2 and their thioanalogues 313benzoylphenylethyl1Hisochromen1thione 3 and 313benzothioyl phenylethyl1Hisochromen1one 5 were successfully obtained in good yield and purity from antiinflammatory drug ketoprofen 1 and its thio analogue 4 The compounds were successfully characterized by FTIR MASS 1HNMR and 13CNMR spectral techniques The in vitro antiinflammatory and antioxidant screening revealed that 313benzoylphenyl ethyl1Hisochromen1one 2 possesses better antioxidant and antiinflammatory activity whereas 313benzoylphenylethyl1Hisochromene1thione 3 and 313benzothioyl phenyl ethyl1Hisochromen1one 5 showed moderate antioxidant activity in comparison to ketoprofen

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