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Title of Journal: Cytotechnology

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Abbravation: Cytotechnology

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Springer Netherlands

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DOI

10.1007/978-3-642-32344-7

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1573-0778

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Implication of SUMO E3 ligases in nucleotide excis

Authors: Maasa Tsuge Hidenori Kaneoka Yusuke Masuda Hiroki Ito Katsuhide Miyake Shinji Iijima
Publish Date: 2014/07/10
Volume: 67, Issue: 4, Pages: 681-687
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Abstract

Posttranslational modifications alter protein function to mediate complex hierarchical regulatory processes that are crucial to eukaryotic cellular function The small ubiquitinlike modifier SUMO is an important posttranslational modification that affects transcriptional regulation nuclear localization and the maintenance of genome stability Nucleotide excision repair NER is a very versatile DNA repair system that is essential for protection against ultraviolet UV irradiation The deficiencies in NER function remarkably increase the risk of skin cancer Recent studies have shown that several NER factors are SUMOylated which influences repair efficiency However how SUMOylation modulates NER has not yet been elucidated In the present study we performed RNAi knockdown of SUMO E3 ligases and found that in addition to PIASy the polycomb protein Pc2 affected the repair of cyclobutane pyrimidine dimers PIAS1 affected both the removal of 64 pyrimidine pyrimidone photoproducts and cyclobutane pyrimidine dimers whereas other SUMO E3 ligases did not affect the removal of either UV lesion

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