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Title of Journal: Indian J Pediatr

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Abbravation: The Indian Journal of Pediatrics

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Springer India

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DOI

10.1002/chem.201603055

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0973-7693

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Impact of availability of oral hydrocortisone on g

Authors: V V Khadilkar A V Khadilkar G B Maskati
Publish Date: 2005/04/01
Volume: 72, Issue: 4, Pages: 301-303
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Abstract

Objectives 1 To compare growth parameters of patients with Congenital Adrenal Hyperplasia CAH managed on Prednisolone PR before and on Hydrocortisone HC after its availability in India 2 To compare growth parameters of patients with CAH who have been on treatment with HC since diagnosis with patients managed on PRMethods Growth parameters of twelve children 8 m 4f with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone PR earlier and then hydrocortisone HC after it became freely available in IndiaResults Patients treated with PR had height Z score of 042 weight Z score of 045 and height velocity Z score of 206 On HC these scores were 027 +016 and + 227 Patients treated with HC from the begining had a height Z Score of + 008 weight Z score of +022 and height velocity Z score of +068Conclusion Hydrocortisone has a less growth effect than prednisolone and patients treated with HC from the beginning showed near normal growth

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