Authors: Abhishek Chopra Virendra Kumar Ashok Dutta
Publish Date: 2011/02/03
Volume: 78, Issue: 7, Pages: 833-837
Abstract
Sixty children between 2 to 12 years of age with septic shock were randomized to receive normal saline or 3 saline as initial resuscitative fluid Fluid resuscitation was done with 09 saline in boluses of 20 ml/kg each bolus over a duration of 15 min with a maximum of 2 boluses Fluid resuscitation with 3 saline was given as a single bolus of 15 ml/kg over 30 min After initial fluid bolus completion if hemodynamic stability was not achieved then further fluid boluses of 09 saline were given in volumes of 5–10 ml/kg guided by CVPThere were 30 patients in both the groups Both the groups were identical with respect to age gender primary diagnosis laboratory parameters initial hemodynamic parameters and PRISM score at time of admission The amount of total fluid bolus required for resuscitation was approximately half in the group who received 3 saline as compared to the group who received 09 saline The use of vasopressor drugs shock reversal time ICU stay and mortality rate were similar in both the groups No adverse effects related to fluid therapy were observed in any of the groupsBoth normal saline and hypertonic saline were equally effective as resuscitation fluid with respect to restoration of hemodynamic stability average duration of ICU stay and mortality Hypertonic saline appears to be a promising fluid for resuscitation of septic shock
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