Authors: Narayan Gyawali Raj Kumari Sanjana
Publish Date: 2012/11/20
Volume: 80, Issue: 5, Pages: 371-374
Abstract
To determine the incidence of neonatal septicemia identify the bacterial isolates and study their antimicrobial susceptibility pattern in neonates visiting outpatient door OPD and admitted to the pediatric ward and neonatal intensive care unit NICU of the College of Medical Sciences Teaching Hospital Chitwan NepalOut of the total 7868 blood culture samples submitted to the microbiology laboratory 1572 1997 samples were from suspected cases of neonatal septicemia The blood culture was positive for neonatal sepsis in 238 1513 samples The incidence of gram positive and gram negative organisms were 441 and 559 respectively Staphylococcus aureus remained the predominant isolate followed by Klebsiella spp Most of the gram positive isolates exhibited higher resistance to penicillin and cephalosporin Susceptibility to commonly used aminoglycosides and quinolones was found Similarly more than two third isolates of gram negative Enterobacteriaceae showed resistance to ampicillin Third generation cephalosporin and aminoglycosides were found to be more satisfactory among gram negative organisms as compared to gram positiveThe high incidence of neonatal septicemia in the present setting reflects high magnitude of problem in central part of Nepal Organisms isolated in the study exhibited higher resistance towards commonly used antimicrobials High resistances to recommended drugs awares health care workers to seek for alternative antimicrobial agents The periodic survey of etiological agents and their antibiotic susceptibility patterns is indeed necessary for the timely alarm of such type of problems
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