Authors: Manisha Kataria Subina Narang Deepak Chawla Sunandan Sood Parul Chawla Gupta
Publish Date: 2015/02/17
Volume: 82, Issue: 8, Pages: 694-697
Abstract
In this randomized controlled trial neonates with type 1 ROP undergoing laser ablation of peripheral retina were randomized to receive or not to receive 2 ml of 25 dextrose orally just before the laser therapy In both the groups topical anesthesia was provided by instilling paracaine eye drops twice at 10 min interval just before the laser treatment Main outcome was Premature Infant Pain Profile PIPP recorded before and 30 s after starting the laser treatmentBirth weight gestation stage and extent of ROP and other baseline variables were comparable among neonates randomized to dextrose n = 12 or control n = 12 groups Both groups required comparable number of laser spots PIPP scores was comparable in neonates randomized to dextrose or control groups and indicated significant amount of pain felt during laser ablation despite local anesthesia with or without oral dextroseSingle dose of oral dextrose did not significantly reduce pain during laser treatment in premature neonates Further studies with multiple doses of dextrose and its combination with other nonpharmacological eg behavioral physical interventions may be neededMK designed the study collected data and wrote first draft of the manuscript SN SS and PCG designed the study performed laser treatment and gave inputs for manuscript writing DC designed the study performed data analysis and gave inputs for manuscript writing All authors have seen the final manuscript and approve it for submission DC will act as guarantor for this paper
Keywords: