Authors: Senol Bozdag Serife Suna Oguz Tulin Gokmen Zuhal Tunay Levent Tok Nurdan Uras Omer Erdeve Ugur Dilmen
Publish Date: 2011/07/06
Volume: 78, Issue: 12, Pages: 1503-1509
Abstract
One hundred sixty seven premature infants who had a birth weight of 1500 g and a gestational age of less than 32 wk were investigated in the present study Blood glucose was measured at the bedside and infants were recorded as hyperglycemic if their mean blood glucose levels were higher than 150 mg/dL Serum corrected fructosamine level was obtained from the cord blood at birth and after the first month of life The infants’ eyes were examined by ophthalmologists to detect retinopathy of prematurity at the gestational age of 32 wk or at four wk after birth whichever came firstCorrected fructosamine was 3196 ± 596 and 2728 ± 506 mmol/l for group1 on 1st and 30th day respectively 320 ± 617 and 2682 ± 473 mmol/l for groups 2 + 3 on 1st and 30th day respectively which did not differ between groups p = 0766 and p = 0665 whereas duration of hyperglycemia was 169 ± 11 day in group 1 compared with 305 ± 24 day in groups 2 + 3 which was significantly different p = 0019 The multivariate regression analysis indicated that the duration of hyperglycemia in days was significantly correlated with the development of retinopathy of prematurity OR 326 95 CI 109–980 p = 0035Although the duration of hyperglycemia may contribute to the development of retinopathy of prematurity serum corrected fructosamine does not have a good predictive value in developing retinopathy of prematurity in verylowbirthweight VLBW infants
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