Authors: Bhavneet Bharti Anjum Grewal Raman Kalia Pragya Pathak
Publish Date: 2010/09/07
Volume: 77, Issue: 11, Pages: 1241-1246
Abstract
This randomized controlled trial was conducted in Vaccination Room of the Advanced Pediatrics Center 155 participants for primary immunization were assigned to two intervention groups 23 vs 25 gauge Parentreported local and systemic reactions were recorded daily for three days after the immunizationSwelling 24 and tenderness 21 were the two most common parentreported local symptoms followed by restriction of movements 18 and redness 10 on day 1 Any local reaction on day 1 was statistically similar in 25 gauge vs 23 gauge group RR 077 95 CI 032 to 182 P = 054 but fever day 1 showed higher trend in 23 gauge needle group RR 224 95 CI 092–547 P = 007 Furthermore on analysis of serially reported local and systemic reactions for 3 consecutive days by generalized estimating equations odds of redness swelling tenderness restricted movement and fever were statistically similar between two needle groups On the other hand median ±SE crying time in seconds was significantly prolonged in the 25 gauge needle 39 ± 2 as compared to 23 gauge group 30 ± 13 log rank test P = 0001The use of same length needles with narrower 25 or wider 23 gauge did not show significant differences in local reactogenicity during primary immunization Fever however was reduced marginally in 25 gauge group whereas crying duration was significantly shorter with 23 gauge needle Finally larger studies are needed to further evaluate objectively the outcome of reactogenicity
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