Authors: Yukiomi Nakade Christopher Mantyh Theodore N Pappas Toku Takahashi
Publish Date: 2007/04/26
Volume: 42, Issue: 4, Pages: 279-282
Abstract
Fecal pellet output has been assessed as a colonic motor activity because of its simplicity However it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output We examined the causal relationship between colonic transit and fecal pellet output stimulated by the central application of corticotropinreleasing factor CRF and restraint stressImmediately after intracisternal injection of CRF 51Cr was injected via a catheter positioned in the proximal colon Ninety minutes after 51Cr injection the total number of excreted feces was counted and then the rats were killed The radioactivity of each colonic segment was evaluated and the geometric center GC of the distribution of 51Cr was calculated For the restraint stress study after administration of 51Cr into the proximal colon rats were submitted to wrapping restraint stress for 90 min Then they were killed and GC was calculatedBoth restraint stress and CRF significantly accelerated colonic transit There was a positive correlation observed between fecal pellet output and GC of colonic transit in response to restraint stress but not CRF when the number of excreted feces was more than three In contrast there was no significant correlation observed between the two in stress and CRF when the number of excreted feces was less than two
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