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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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10.1007/978-1-4899-2623-4_10

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1435-5922

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Mast cells are involved in the pathogenesis of ind

Authors: Tetsuya Okayama Norimasa Yoshida Kazuhiko Uchiyama Tomohisa Takagi Hiroshi Ichikawa Toshikazu Yoshikawa
Publish Date: 2009/01/16
Volume: 44, Issue: 19, Pages: 35-39
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Abstract

Nonsteroidal antiinflammatory drug NSAIDinduced enteropathy is clinically very important but the pathological mechanisms remain unclear Mast cells have been reported to play an important role in the pathogenesis of indomethacininduced small intestinal injury In this study we investigated the role of mast cells in indomethacininduced small intestinal injury using mast cell deficiency Ws/Ws ratThe area mm2 of macroscopic visible lesions the concentrations of thiobarbituric acidreactive substances TBARS as an index of lipid peroxidation myeloperoxidase MPO activity as an index of neutrophil accumulation and the content of cytokineinduced neutrophil chemoattractant1 CINC1 were significantly increased in indomethacintreated groups compared with the sham groups The development of intestinal lesions in response to indomethacin was prevented in Ws/Ws rats compared with W+/W+ rats together with significant suppression of the increased levels of TBARS MPO activities and CINC1 levels

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