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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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DOI

10.1007/bf01747213

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1435-5922

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Vitamin K deficiency leads to exacerbation of muri

Authors: Eri Shiraishi Hideki Iijima Shinichiro Shinzaki Sachiko Nakajima Takahiro Inoue Satoshi Hiyama Shoichiro Kawai Manabu Araki Toshio Yamaguchi Yoshito Hayashi Hironobu Fujii Tsutomu Nishida Masahiko Tsujii Tetsuo Takehara
Publish Date: 2015/08/28
Volume: 51, Issue: 4, Pages: 346-356
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Abstract

Colitis was induced using dextran sulfate sodium DSS in mice fed either a vitamin Kdeficient Kdef or a vitamin Ksupplemented Ksup diet The clinical and histological severity of colitis was assessed and levels of cytokine production from the spleen and colonic lamina propria were measured by enzymelinked immunosorbent assay and quantitative realtime reverse transcription polymerase chain reaction Cytokine expression levels in CD4+ CD11b+ and CD19+ cells in the presence and absence of vitamin K menatetrenone MK4 were measured in vitro and apoptosis was determined by caspase 3/7 activity and Annexin V stainingDSS administration resulted in significantly more severe body weight loss shorter colon length and higher histological scores in mice fed a Kdef diet than those fed a Ksup diet IL6 expression in lamina propria mononuclear cells was significantly higher in the Kdef group than in the Ksup group IL6 expression was significantly decreased in the presence of MK4 in CD19+ cells but not in the CD4+ and CD11b+ subpopulations Apoptotic cell population in CD19+ cells was increased in the presence of MK4 in vitro and in vivo

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