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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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DOI

10.1016/0001-6160(78)90205-5

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1435-5922

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Is a fecal occult blood test a useful tool for jud

Authors: Hiroki Endo Takayuki Kato Eiji Sakai Leo Taniguchi Jun Arimoto Harunobu Kawamura Takuma Higurashi Hidenori Ohkubo Takashi Nonaka Masataka Taguri Masahiko Inamori Takeharu Yamanaka Takashi Sakaguchi Yasuo Hata Hajime Nagase Atsushi Nakajima
Publish Date: 2016/04/19
Volume: 52, Issue: 2, Pages: 194-202
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Abstract

Aspirin use is reportedly not to be associated with fecal immunochemical occult blood test FIT falsepositive results for the detection of colorectal cancer The need for additional small bowel exploration in FITpositive lowdose aspirin users with a negative colonoscopy is controversial The aim of this study was to assess the ability of FIT to judge whether capsule endoscopy CE should be performed in lowdose aspirin users with negative colonoscopy and esophagogastroduodenoscopy findings by comparing FIT results with CE findingsA total of 264 consecutive lowdose aspirin users with negative colonoscopy and esophagogastroduodenoscopy who were scheduled to undergo CE at five hospitals in Japan were enrolled Patients had been offered FIT prior to the CE The association between the FIT results and the CE findings was then assessedOne hundred and fiftyseven patients were included in the final analysis Eightyfour patients 535  had positive FIT results The sensitivity specificity positive predictive value PPV and negative predictive value NPV of positive FIT results for small bowel ulcers were 056 047 030 and 073 respectively Furthermore the NPV of positive FIT results for severe small bowel injury Lewis score ≥790 was markedly high 090 When the analysis was performed only in lowdose aspirin users with anemia the sensitivity of the positive FIT results was notably improved 072

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