Authors: JingHoung Wang ChiSin Changchien ChaoHung Hung HockLiew Eng WeiChih Tung KwongMing Kee ChienHung Chen TsungHui Hu ChuanMo Lee ShengNan Lu
Publish Date: 2009/03/25
Volume: 44, Issue: 5, Pages: 439-446
Abstract
Consecutive patients with chronic hepatitis B HBV or hepatitis C virus HCV infections with indications for liver biopsy were prospectively enrolled LSM was performed on the same day as biopsy US scores including assessment of liver surface liver parenchyma intrahepatic vessels and spleen index were used to assess the degree of hepatic fibrosis The pathological findings were used as a reference standard and diagnostic accuracy was assessed and comparedThreehundred and twenty patients including 199 men and 121 women with a mean age of 508 years were analyzed There were 214 669 HCV patients 88 275 HBV patients and 18 56 patients with both HCV and HBV LSM correlated significantly with the hepatic fibrosis F scores necroinflammatory activity and US scores in multivariate analysis The diagnostic accuracy of LSM is significantly superior to US and equal to combined LSM with US in the prediction of all HCVrelated fibrosis scores The cutoff value of LSM is 6 kPa for diagnosing F =1 with a positive predictive value of 91 Also the cutoff value is 12 kPa for the prediction of cirrhosis with a negative predictive value of 94
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