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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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DOI

10.1016/0006-8993(74)90810-5

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1435-5922

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Effects of transjugular intrahepatic portosystemic

Authors: Yoko Matsushita Yoshiyuki Narahara Shunji Fujimori Hidenori Kanazawa Norio Itokawa Takeshi Fukuda Yoko Takahashi Chisa Kondo Hideko Kidokoro Masanori Atsukawa Katsuhisa Nakatsuka Choitsu Sakamoto
Publish Date: 2012/09/13
Volume: 48, Issue: 5, Pages: 633-639
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Abstract

The introduction of capsule endoscopy CE has facilitated the detection of mucosal changes in the small bowel and such mucosal changes have been noted in cirrhotic patients with portal hypertension these changes are described as portal hypertensive enteropathy The aim of this study was to assess the effects of transjugular intrahepatic portosystemic shunt TIPS on the small bowel mucosal changes detected by CE in cirrhotic patients with portal hypertensionTIPS was performed in fifteen cirrhotic patients with portal hypertension All patients underwent CE before and 2 weeks after TIPS The small bowel mucosal changes were defined as edema angiodysplasialike lesions red spots and small bowel varices Changes in the portosystemic pressure gradient PSG and CE findings were evaluatedBefore TIPS small bowel edema was detected in all 15 patients angiodysplasialike lesions in 7 and red spots in 14 patients The PSG decreased significantly from 212 ± 26 before TIPS to 89 ± 33 mmHg p  0001 after the procedure After TIPS the small bowel edema was attenuated in 8 of the 15 patients In two patients with angiodysplasialike lesions and 4 with red spots these lesions were attenuated after TIPS The average score for small bowel edema and the grade of red spots were reduced significantly after TIPS 23 ± 07–18 ± 06 p  0005 and 16 ± 09–13 ± 07 p  005 respectively Small bowel varices were seen in 4 patients before TIPS and all these varices disappeared after TIPS

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