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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer-Verlag

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1435-5922

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Drug resistance in antiviral treatment for infecti

Authors: Hiroshi Yotsuyanagi Kazuhiko Koike
Publish Date: 2007/05/25
Volume: 42, Issue: 5, Pages: 329-335
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Abstract

Treatments for infections with hepatitis B and C viruses have recently developed markedly and range from nonspecific interferonbased treatments to specific antiviral treatments such as those that inhibit hepatitis viruscoded protein production or activity These developments have contributed to the achievement of excellent enhancement of the antiviral effect On the other hand the development of specific antiviral therapies has created unprecedented problems Antiviral drugresistant strains of viruses have emerged leading to a poor prognosis for infected patients Clarification of the mechanisms underlying the emergence of such resistance to drugs will be useful for the treatment of such patients In this review we outline pathological conditions associated with hepatitis B and C viruses and their treatments and discuss the current situation and mechanisms underlying the emergence of antiviral drugresistant strains

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Other Papers In This Journal:
  1. Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma
  2. Genotype 3 and higher low-density lipoprotein levels are predictors of good response to treatment of recurrent hepatitis C following living donor liver transplantation
  3. Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1
  4. Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan
  5. A fatal case of progressive steatohepatitis, possibly chemotherapy-associated steatohepatitis related to gemcitabine
  6. Pathophysiological mechanisms in acute pancreatitis: Current understanding
  7. Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3
  8. Quantitative cholescintigraphy with fatty meal in the diagnosis of Sphincter of Oddi dysfunction and acalculous cholecystopathy
  9. Effects of transjugular intrahepatic portosystemic shunt on changes in the small bowel mucosa of cirrhotic patients with portal hypertension
  10. Combined effect of proton-pump inhibitors and other drugs with regard to lower gastrointestinal tract bleeding with special reference to low-dose aspirin
  11. Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis
  12. Gemcitabine as first-line chemotherapy in elderly patients with unresectable pancreatic carcinoma
  13. Color Doppler—An effective tool for diagnosing midgut volvulus with malrotation
  14. Extensive 0-IIc (undifferentiated carcinoma) lesion around a gastric adenoma: a case report
  15. Hepatocellular carcinoma with gastric metastasis treated by simultaneous hepatic and gastric resection: report of a case
  16. A case of peripancreatic tuberculous lymphadenitis diagnosed by endoscopic ultrasound-guided fine-needle aspiration
  17. Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis
  18. Association between adherence to evidence-based guidelines for the prescription of non-steroidal anti-inflammatory drugs and the incidence of gastric mucosal lesions in Japanese patients
  19. Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk
  20. Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice
  21. Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice
  22. Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis
  23. Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis
  24. Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis
  25. Long-term outcomes of patients with metastatic gastric cancer after initial S-1 monotherapy
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  27. Society of Gastrointestinal Endoscopy of India
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  29. Clostridium difficile as a cause of acute diarrhea: a prospective study in a tertiary care center
  30. Gastrointestinal complications in renal transplant recipients detected by endoscopic biopsies in a developing country
  31. Long-term follow-up of common bile duct diameter after endoscopic sphincterotomy in patients with common bile duct stones
  32. Long-term surviving patient with inferior vena cava tumor thrombus and extrahepatic metastasis after spontaneous ruptured hepatocellular carcinoma
  33. Dysfunction of a port-catheter system percutaneously implanted for hepatic arterial infusion chemotherapy due to a fibrin sheath
  34. Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis
  35. Diagnosis of pT2 gallbladder cancer by serial examinations with endoscopic ultrasound and angiography
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  48. Hypocalcemia secondary to hypomagnesemia in a patient with Crohn’s disease
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  52. Is a fecal occult blood test a useful tool for judging whether to perform capsule endoscopy in low-dose aspirin users with negative colonoscopy and esophagogastroduodenoscopy?
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  63. Factors influencing the accuracy of EUS FNA: do educational elements matter?
  64. Overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis triggered by fluvastatin
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  66. A rare ring-shaped anomaly of the main pancreatic duct accompanying a branch duct IPMN
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